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Semaglutide mimics the function of the naturally occurring GLP-1 hormone, which is an incretin released by the digestive tract after food consumption to stimulate insulin release [8] Semaglutide has a similar affinity to the GLP-1 receptors in the exocrine pancreas as native GLP-1(7-37), which results in [3]: Activation of pancreatic beta cell function and increased insulin production, and Suppression of pancreatic alpha cell function and reduced production of glucagon