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Byetta (immediate-release) : Half-life of 2.4 hours, requiring twice-daily subcutaneous injection 60 minutes before meals Bydureon (extended-release) : Exenatide encapsulated in biodegradable poly(D,L-lactide-co-glycolide) microspheres that release the peptide over weeks, enabling once-weekly dosing with a half-life of approximately 2 weeks Semaglutide: Human GLP-1 Based# Semaglutide is a 31-amino acid peptide with 94% homology to native human GLP-1

discussion 1152-60, 2004

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Treatment with exenatide, a GLP-1 receptor agonist, was comparable to placebo in slowing the rate of Parkinsons disease progression over 96 weeks of treatment, according to a phase 3 study published in The Lancet