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In dermal wound models using full-thickness punch wounds in mice and rats, topical application (5-50 g per wound) accelerated closure, enhanced collagen deposition, and promoted angiogenesiseffects maintained even in diabetic, aged, or corticosteroid-suppressed animals
Following a vegan or vegetarian diet, having gastrointestinal issues, having pernicious anemia, and taking specific drugs are issues that frequently result in a deficiency
In fibroblast cultures, biochemical assays show increased cell migration, enhanced cytoskeletal organization, and improved survival under oxidative stress conditions