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Gamma-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO

Stem Cells Int 2015:379093 Margaritelis NV, Theodorou AA, Paschalis V, Veskoukis AS, Dipla K, Zafeiridis A, Panayiotou G, Vrabas IS, Kyparos A, Nikolaidis MG (2018) Adaptations to endurance training depend on exercise-induced oxidative stress: exploiting redox interindividual variability

Because it avoids hepatic first-pass metabolism, circulating citrulline is primarily cleared by the proximal renal tubule, where it is enzymatically converted to arginine

Biochem J 104:627633 Richardson MP, Ayliffe MJ, Helbert M, Davies EG (1998) A simple flow cytometry assay using dihydrorhodamine for the measurement of the neutrophil respiratory burst in whole blood: comparison with the quantitative nitrobluetetrazolium test