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De Vadder and colleagues [181] made an important discovery when they identified that butyrate and propionate, produced during the breakdown of soluble fiber by gut microbiota, could promote the activation of genes linked to intestinal gluconeogenesis

More than one billion people worldwide are living with obesity, which increases their risk of major health complications, including T2D, high blood pressure, heart disease, stroke, metabolic syndrome, fatty liver diseases, some cancers, kidney disease, breathing problems, and sleep apnea

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That's why it's so important to understand why someone is struggling before considering whether a GLP-1 medication is appropriate