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The foods most likely to work against your GLP-1 therapy: Sugary beverages and foods juice, soda, candy, and sweetened coffee drinks cause rapid blood sugar spikes that counteract the medication's stabilizing effect Refined carbohydrates white bread, regular pasta, crackers, and pastries digest quickly and spike blood sugar in ways fiber-rich whole grains don't High-saturated-fat foods fried foods, fatty processed meats, and baked goods high in butter or shortening slow gastric emptying beyond what's therapeutic, which can worsen nausea and discomfort Can You Drink Alcohol While on GLP-1 Medications