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Glutathione peroxidase 4 (GPX4) acts as a master regulator in the ferroptosis process, and its unique function is to interrupt lipid peroxidation by converting lipid hydroperoxides into non-toxic lipid alcohols [5]
Miotto G, Rossetto M, Di Paolo ML, Orian L, Venerando R, Roveri A, Vuckovic AM, Bosello Travain V, Zaccarin M, Zennaro L, et al
It does, however, possess the genes to recycle GSH from its oxidised to reduced states, as well as glutathione S-transferases (GSTs) which use GSH to post-translationally modify other proteins
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