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Effects of acetyl-L-carnitine oral administration on lymphocyte antibacterial activity and TNF-alpha levels in patients with active pulmonary tuberculosis

4 Adverse events in PIONEER 3 1,4 Comparator AE rates are not an adequate basis for comparison of safety between products 1 Because clinical trials are conducted under widely varying conditions, AE rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice 1 AE=adverse event

Having a strategy in place before stoppingsuch as transitioning to a lower maintenance dose or structured lifestyle supportsignificantly reduces rebound risk

The overall clinical significance is limited