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Preventing the progression from prediabetes to type 2 diabetes avoids years of glycemic damage to the vasculature, kidneys, and nerves before the diagnosis is even made

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Tolerance to side effects is a well-recognised phenomenon with GLP-1 receptor agonists

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Liraglutide (marketed as Victoza for diabetes, Saxenda for obesity) was the first GLP-1 agonist approved for chronic weight management (FDA 2014), while semaglutide (Ozempic/Wegovy/Rybelsus) arrived later with improved pharmacokinetics and substantially greater efficacy

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