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Risk factors that should prompt consideration of B12 deficiency include advancing age (reduced stomach acid production), strict vegan or vegetarian diets, pernicious anaemia, gastrointestinal surgery (particularly gastric bypass or ileal resection), long-term use of certain medications (metformin, proton pump inhibitors, H2-receptor antagonists), nitrous oxide exposure (including recreational use), and conditions affecting the gut such as Crohn's disease or coeliac disease
The remaining 158,349 patients who did not use GLP-1 RAs were enrolled as the GLP-1 RAs non-users group
Adjusting Treatment Plans As treatment progresses, adjustments may be necessary based on the patient's response to the medication combination
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