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Cardiologists will need to counsel patients through that and acclimate them to giving these drugs by subcutaneous injection. Meanwhile, he adds, future research is needed to address whether semaglutide exerts the same protective effects for primary prevention of cardiovascular disease in high-risk individuals with overweight or obesity

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Importantly, the benefit of GLP-1 receptor agonists injected weekly was also shown to be the same as that of agents injected daily, the researchers wrote