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As a result, E 3.50 engages Y 7.57 with a hydrogen bond, stabilizing the active state of the receptor (Figure 17) in comparison to the inactive (PDB: 6LN2) GLP-1R ( FIGURE 17 5 Conclusion The expression of GLP-1R in tissues other than the pancreas, such as the brain, endocrine tissues, heart muscle, kidneys, lungs, muscle, and vascular tissues, as well as the proximal digestive and gastrointestinal tract, indicates that GLP-1 has a multifaceted regulatory role beyond glucose homeostasis mediated by insulin release
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