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Despite the pleiotropic properties of GLP-1, including its insulinotropic effect found in rats, pigs, and humans, its extremely short plasma half-life of less than 2 minutes constituted a huge brick wall in the path of GLP-1 to be developed as a glucose-lowering medication

FDA may be more cautious with a novel receptor combination, and the unresolved TRIUMPH-3 MACE question could invite additional review time

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