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The American Society of Anesthesiologists suggests withholding GLP-1 medications before elective surgery to reduce the risk of complications, and this is something your doctor can help with, should you have an upcoming operation
However, combining compounds that both increase metabolic rate and appetite (MK-677 elevates ghrelin, Tesofensine suppresses appetite via catecholamine modulation) creates competing physiological signals that may reduce the effectiveness of either compound
These considerations are routinely accounted for within controlled study protocols
Tesamorelin is best known for its connection to visceral fat reduction, especially abdominal fat stored deeper around internal organs
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