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f , Left, volcano plot showing relative fold change (log 2 ) in whole cell metabolite abundance versus log 10 (P value) from KPK cells expressing a sgRNA targeting intergenic region or sgRNA targeting Slc33a1
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Glutathione is a powerful antioxidant that is naturally found in the liver
Combined these results indicated that NP4 catalyzes the generation of H 2 O 2 in tumor cells, which diffuses outside the cells and activates macrophages, thereby triggering immune responses
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