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There are few Pro specific proteases and these include DPP4 and FAP (the type II integral membrane proteins), intracellular DPPII/DPP7 that localizes to the vesicular system, soluble and cytosolic DPP8 and DPP9, and intracellular prolyl oligopeptidase (POP)
For the amylin combination, Enebo et al., 2021 described a similar tolerability pattern
Glucagon-like peptide-1 infusion must be maintained for 24 h/day to obtain acceptable glycemia in type 2 diabetic patients who are poorly controlled on sulphonylurea treatment
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