Maquart FX, Bellon G, Chaqour B, et al
Conducted between June 2011 and March 2013 at 191 sites in 27 countries in Europe, North America, South America, Asia, and Australia this was a randomised, placebo-controlled trial designed to evaluate the efficacy and safety of 3mg liraglutide 'injected subcutaneously once daily, as an adjunct to a reduced-calorie diet and increased physical activity, for weight management in overweight or obese adults who did not have diabetes at baseline.' A total of 3,731 individuals participated in the trial, of whom 2,487 were assigned to lifestyle intervention plus liraglutide and 1,244 to lifestyle intervention with a placebo
The effects of GLP1RAs are sought to be exploited in the treatment of several other conditions, including prediabetes, T1DM, obesity and liver disease
Annalise Schoonmaker , Claudius Mueller, Emanuel F