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Severe gastrointestinal adverse reactions , including stomach paralysis
Sustained, significant weight loss
Tirzepatide, marketed as Mounjaro for type 2 diabetes and Zepbound for weight management, is an FDA-approved dual GIP and GLP-1 receptor agonist that requires careful administration to maximize benefits and minimize risks
Additionally, conflicting findings suggest that prolonged metformin treatment may exacerbate AD pathology in genetically susceptible models, increasing -amyloid accumulation, tau phosphorylation, and synaptic dysfunction 92
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