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Understanding the precise mechanism by which GLP-1 agonists work is essential when evaluating whether other compounds, such as berberine, share similar pharmacological properties

Its efficacy and relative safety have made it a preferred choice for many healthcare providers and patients

A limitation with the use of GLUTag cells, as well as other models for epithelial cells, is that the cells have lost their polarization, which may affect the amino acid sensing mechanisms, as different amino acid transporters are situated on the apical compared to the basolateral membrane [28]

The delay of any of the factors in gastric emptying causes disorganization or reduced frequency of antral contractions and thus delayed GE