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Some chemotherapy drugs or antiretroviral medications (for HIV) that suppress bone marrow might also blunt the effectiveness of B therapy

In a rat model of intervertebral disc degeneration, MOTS-c injection preserved disc height (82.4% versus 58.7% in the untreated group), restored MRI signals indicating improved disc hydration, and reduced histological degeneration scores by 44% compared to untreated controls

Shureiqi I, Jiang W, Zuo X, Wu Y, Stimmel JB, Leesnitzer LM, Morris JS, Fan H-Z, Fischer SM, Lippman SM (2003) The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells