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Phase 3 CagriSema (Garvey et al., NEJM 2025
Hyperglycemia may directly cause oxidative stress in all retinal cells or contribute to oxygen deficits in the inner retinal layers due to the retinas high metabolic activity, making it prone to oxidative stress
The mTORC1 inhibition by AMPK is accomplished by direct phosphorylation of the regulatory-associated protein of mTOR (Raptor) [264] and indirectly via activation of TSC2 [265, 266]
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