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While a causal relationship has not been established, patients with depression or other psychiatric conditions should be monitored for changes in mood or behavior, particularly during the initial weeks of treatment or following dose adjustments

Its not a general pick-me-up or a cure-all for tiredness stemming from other causes

How Vitamin B12 Supports Nervous System Health The nervous system depends on steady vitamin B12 levels to work correctly

Over the following weeks most people notice subtle metabolic shifts and reduced bloating first (weeks 12), then more noticeable body-composition change around the midsection (weeks 24), then visible fat loss with muscle preserved (weeks 48), with the best results from week 8 onward, diet and exercise still do the heavy lifting