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Obesity and visceral adiposity are key drivers of HFpEF development and progression, and this may be even more amplified in women, who represent the majority of people with the disease, and bear a heavier burden of symptoms and physical limitations due to HFpEF

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In STEP 1, about 86.4% of semaglutide participants lost at least 5% of body weight, 69.1% lost at least 10%, and 50.5% lost at least 15% (versus 31.5%, 12.0%, and 4.9% on placebo)

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