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The ACO1 gene is located on chromosome 9p21.1 and is composed of 23 exons that generate three alternatively spliced mRNAs, each of which encode the same protein of 889 amino acids

no formal human PK studies) ~2-4 hours (estimated, polypeptide complex) ~2-4 hours (estimated, short peptide complex) ~0.5-1 hour (estimated from tetrapeptide class) ~3 hours (terminal elimination after SC/IV

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