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Understand the profound difference in bioavailability

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These medications bind to receptors throughout the body, including the brain, pancreas, and gastrointestinal tract

The Label Language That Governs This Section 5.1 of the phentermine labeling is explicit: phentermine is indicated only as short-term monotherapy for the management of exogenous obesity, and the safety and efficacy of combination therapy with any other weight-loss drug products prescription, over-the-counter, or herbal or with serotonergic agents such as selective serotonin reuptake inhibitors have not been established