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small absolute numbers) Palpitations: up to 3.2% (12 mg) Sinus tachycardia: up to 3.2% (12 mg) QT prolongation on ECG: 1.6% (12 mg) Retatrutide's Heart Rate Effects and Arrhythmia Risk in Obesity Trials Retatrutide and Cardiac Rhythm Safety Dose-Dependent Heart Rate Increase With Low Incidence of Clinically Significant Arrhythmias in Phase 2 Obesity Trials Background Retatrutide (LY3437943) is a novel triple agonist targeting GIP, GLP-1, and glucagon receptors, developed for the treatment of obesity and cardiometabolic disease

In summary, Ozempic, Wegovy, Rybelsus, and Mounjaro are newer-generation medications that help regulate appetite, blood sugar, and weight

Update on FDAs Ongoing Evaluation of Reports of Suicidal Thoughts or Actions in Patients Taking a Certain Type of Medicines Approved for Type 2 Diabetes and Obesity