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CPP-CAND targets the well-ordered FOXO4 FHD domain, contributing to its high selectivity for senescent cells
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During the initiation and early stages of tumors, the studies show that increased ROS levels under organochlorine pesticide exposure are accompanied by induction of inflammatory cytokines and DNA damage markers, suggesting that a ROS-mediated inflammation-genomic damage axis may function as an early event that creates a carcinogenic priming environment in ovarian epithelial cells
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