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Dan Witters, Gallup's research director for the National Health and Well-Being Index, described the dynamic in the survey report: "The lower cost of compounded or custom-mixed varieties is fueling a shift away from brand-name choices and is likely making GLP-1s available to broader sectors of the population." The Gallup data also illustrate an interesting efficacy perception gap: 39 percent of compounded GLP-1 users said their medication was "extremely effective," compared with 32 percent of brand-name users though researchers and regulators caution that compounded versions have not undergone the same clinical testing as FDA-approved drugs

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The activation of GLP-1R is associated with glucose-induced insulin secretion and inhibition of -cell glucagon release [43]