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Study design and study population We identified three study cohorts of patients who started SGLT-2 inhibitors versus DPP-4 inhibitors (cohort 1), GLP-1 receptor agonists versus DPP-4 inhibitors (cohort 2), and SGLT-2 inhibitors versus GLP-1 receptor agonists (cohort 3) from April 2013 to the end of available data (December 2019 in Medicare, December 2020 in MarketScan, and April 2022 in CDM)

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