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It was demonstrated that cysteine S -conjugate -lyase highly expressed in the kidney was responsible for the observed nephrotoxicity (Zhang and Hanigan, 2003

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doi:10.1021/bi400651x Go YM, Roede JR, Walkers D, Duong DM, Seyfried NT, Orr M, Liang Y, Pennell KD, Jones DP (2013) Selective targeting of the cysteine proteome by thioredoxin and glutathione redox systems

In conclusion, our results clearly demonstrate that Cr can effectively protect human erythrocytes and lymphocytes from damage induced by oxidizing agents