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This metabolic dysregulation is defined by systemically reduced levels of metabolites such as amino acids and fatty acids, leading to reduced TCA cycle activity and oxidative phosphorylation, which may ultimately be a major contributor to neuropsychiatric symptoms associated with reduced energy, such as fatigue and other cognitive impairments [43, 62]
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Peddada, S
Furthermore, oxidative stress and free radical production are increased because astrocytes, which maintain the integrity of the bloodbrain barrier, are targets of oxidative damage (Carvajal-Flores et al
