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10.1016/S2213-8587(19)30066-X Summary Keywords glucagon-like peptide-1 receptor agonists, sodium-glucose co-transporter-2 inhibitors, combination therapy, type 2 diabetes mellitus, meta-analysis Citation Li C, Luo J, Jiang M and Wang K (2022) The Efficacy and Safety of the Combination Therapy With GLP-1 Receptor Agonists and SGLT-2 Inhibitors in Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis

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Tirzepatide pushed those numbers even higher in the SURMOUNT-1 trial, with the top dose producing close to 21 percent average weight loss (Jastreboff et al., 2022)