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Because standard gastrointestinal absorption of B12 is highly complex and easily disrupted by age, low stomach acid, medications, and chronic inflammation, therapeutic dosing often needs to be significantly higher than the standard Recommended Daily Allowance (RDA) of 2.4 mcg
Thats because utilization of vitamin B12 (especially from supplements) depends on levels of other metabolic cofactors and acids
Measurable weight loss usually becomes apparent within 4-6 weeks
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