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Vitamin B12 can reduce the effectiveness of this medication: Tetracycline, an antibiotic used to treat many bacterial infections Here is a list of the medications found to reduce vitamin B12 levels: Aminosalicyclic Acid for Chrohns, Tuberculosis, arthritis and more Anticonvulsants taken to treat epilepsy or bipolar disorder Chloramphenicol for conjunctivitis Colchicine used to treat gout H2 blockers taken for heartburn Metformin used to treat Type 2 diabetes Omeprazole for treating GERD Dont forget the generic forms of these medicines have the same issues