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Flubendazole inhibits the proliferation of CRPC by inhibiting the expression of SLC7A11 by inducing p53, further downregulating glutathione peroxidase 4 (GPX4), and promoting ferroptosis

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Ferroptosis in TECs is repaired in GPX4-overexpressing mice during UUO The findings of pharmacological experiments effectively illustrated that inhibiting TEC ferroptosis can rescue renal fibrosis through TGF-/Smad signaling