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Sex-Dependent effects of developmental arsenic exposure on methylation capacity and methylation regulation of the glucocorticoid receptor system in the embryonic mouse brain." in:: " Toxicology reports , Vol
The 4-PBA group showed mild sinusoidal congestion with focal hepatocyte necrosis as manifested by nuclear pyknosis, karyorrhexis, and karyolysis with cytoplasmic eosinophilia (Figure 8A), yet it significantly attenuated histopathological scoring compared to MTX-group (Figures 8BD)
This property has supported its use in epigenetic and gene-regulation research , rather than as a general signaling peptide acting at surface receptors
Tissues were weighed then homogenized using Qiagens TissueLyzer in 800 l ice-cold 50:50 methanol:water solution per 50 mg tissue, with BIS-TRIS (Sigma-Aldrich) at 125 ng/ml was used as an internal control, in 2 ml microtubes containing one 3 mm Tungsten carbide bead (Qiagen), for 10 min at a frequency of 25 Hertz
