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The localization of FUNDC1 at ER-mitochondria contact sites (MAMs) and its role in integrating mitophagy, mitochondrial adaptation, and ER stress responses exemplify how spatial organization determines functional proteostasis outcomes

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Preliminary data published in June 2023 also suggests that GLP-1 drugs 'could modulate crucial pathways in the pathogenesis of inflammatory bowel disease (IBD), such as chronic inflammation circuits, intestinal tight junctions, and gut microbiome dysbiosis, setting the stage for human trials to investigate the role of these agents in the treatment of IBD among people with or without diabetes and obesity' (Arvanitakis, Theocharis, Popovic