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Orforglipron (OFG), an oral, once daily, non-peptide GLP-1 receptor agonist, demonstrated effective weight loss of up to 10.1 kg at 26 weeks in T2D, and up to 15.4 kg at 36 weeks in participants with obesity without T2D [25, 26]
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Intact and total AMG 133 exposures more closely approximate each other in the initial phase of the study than in the terminal phase (Fig
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