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The SURPASS trials showed that tirzepatide achieved significant HbA1c reductions and was not linked to NPDR progression compared to placebo (178)

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Beside methionine oxidation and protein N-terminal acetylation, following cysteine modifications were considered as variable modifications: sulfinic acid, sulfonic acid N-ethylmaleimide, glutathione, disulfide (-H)

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It facilitates the transportation of fatty acids into the mitochondria, where they are converted into usable energy

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