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MacDonald PE, El-Kholy W, Riedel MJ, et al
Key trials included SUSTAIN 6, a cardiovascular outcomes trial demonstrating significant reduction in major adverse cardiovascular events (MACE) compared to placebo (HR 0.74
This effect is mediated through the downregulation of oxidative and melanogenic signaling pathways, including the cAMP and Wnt pathways, thereby contributing to the restoration of redox homeostasis 186
It has been demonstrated that the expression of the purine-free/pyrimidine-free nucleic acid endonuclease 1 (APE1) is downregulated in gastric host cells infected with H
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