Vukojevi, J., Milavi, M., Perovi, D., Ili, S., ili, A
High intracellular GSH is associated with drug resistance by promoting drug conjugation and transport-mediated efflux
2 Intracellular GSH production is dispensable for tumor growth in the mouse flank
Furthermore, the use of synthetic biology and metabolic engineering has further facilitated these processes, leading to significant advancements in PET biodegradation (Shi et al., 2023), dual-enzyme systems (Xue et al., 2024), and microbial consortia (Salinas et al., 2025), which have demonstrated significant potential in overcoming critical barriers such as intermediate metabolite accumulation and hydrophobic substrate interactions