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Irisin reduces microglia-induced inflammatory responses To investigate whether irisin mitigates microglial activation in MPTP-treated mice, we observed that microglia in the midbrain of MPTP-treated mice exhibited augmented cell size, along with increased branching and more complex morphological features compared to control mice (Fig

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doi: 10.1038/nature12940 501 PantazisNPapastamopoulosVPaparizosVMetallidisSAdamisGAntoniadouAet al