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The following antibodies were used for ChIP assay: anti-ACTL6A (Abcam, ab3882), anti-NRF2 (Cell Signaling Technology, 12721 s), and Rabbit IgG (ab37415) (Abcam, Cambridge, MA)

This lactic acid buildup in the muscles and brain is a primary driver of the heavy, burning muscle pain and profound cognitive fatigue experienced during post-exertional malaise (PEM)

Back Holst, JJ, rskov,C, Schwartz, TW, et al (29 Aug 1986) 'Proglucagon 78-107, a potent insulinotropic hormone from lower smaller intestine', Diabetologia:Abstracts , 511A-610A.Back Holst, JJ, rskov, C, Vagn Nielsen, O, Schwartz, TW (1987) 'Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut', FEBS letters , 211/2

Luckily, most people find GLP-1-related constipation manageable