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Research in animal models suggests that nausea associated with peripheral GLP-1 receptor agonist administration involves activation of central GLP-1 receptors in these brainstem regions that control emesis

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Ipamorelin eliminates these confounds, enabling clean attribution of all observed downstream biology to GH-specific mechanisms and serving as the essential selective control in comparative GH secretagogue study designs

After 48 weeks of the combination at the top dose, that went down by eight inches