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Go low and slow Incretin-based medicines are typically started at a minimum dose, and the dose increases each month or so
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While GLP- 1 RAs were initially exploited for their effects on insulin sensitivity and glucagon secretion, the Nutrient Stimulated Hormones being targeted have effects on muscle protein synthesis and even energy expensiture [42,43,44]
The effect on severe hypoglycemia (RR, 0.78 [95% CI, 0.581.03]) was also similar regardless of baseline SGLT2 inhibitor use ( P -heterogeneity=0.50
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