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[30] [31] [32] [33] An anti-inflammatory effect appears to be the most significant

Additional clinical considerations include: previous weight loss attempts (lifestyle modifications should generally be attempted first), cardiovascular risk profile, family history of medullary thyroid carcinoma (a contraindication for GLP-1 agonists), history of pancreatitis, current medications, mental health status, and pregnancy planning (GLP-1 agonists must be discontinued at least 2 months before conception)

Few people witness severe fatigue along with morning stiffness without even realising that an inflammatory process is already underway

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