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Other patients reported self-limited rectal bleeding not requiring active management (19 patients, 51.4%) or did not report any rectal bleeding (9 patients, 24.3%)
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Lastly, while APOE effects dominated brain profiles, sex effects were more prominent in the periphery, which was also in accordance with a previous study in older (16 months old) APOE-TR mice (Shang et al., 2020), suggesting that regardless of age APOE has a major effect on brain bioenergetics
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