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In an open-label RCT ( n = 96), oral administration of melatonin tablets (3 mg/d, 1 h before sleep, for 7 days) with standard treatment, substantially improved sleep quality and blood O 2 saturation parameters in hospitalized COVID-19 patients 667

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Notably, a similar phenomenon was observed in neurons from patients with MS, characterized by upregulated STING expression and markedly reduced STIM1 expression, suggesting that STIM1-STING-GPX4 axis-mediated ferroptosis is closely associated with neuronal injury in human MS pathology (Woo et al., 2024)