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Microglial activation is a hallmark of AD, initially serving a protective role but becoming detrimental upon chronic stimulation (Li et al., 2021)
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Treatment discontinuation due to side effects occurred in 4.3%, 7.1%, 6.2%, and 2.6% of participants in the 5, 10, 15 mg, and placebo groups, respectively [18]
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The implication is profound: Met carriers get less neurotrophic benefit from the very activities that should boost their brain health the most
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