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Despite support from some groups for the forward-looking approach to rein in healthcare costs long-term and dramatically improve health outcomes, other stakeholders, like the Alliance for Community Health Plans, worried the policy would be a financial catastrophe to the healthcare system

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Vitamin D itself is hydroxylated by CYP27B1 in the kidney and CYP2R1 in the liver to form calcitriol, then catabolized by CYP24A1